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ea0077p54 | Metabolism, Obesity and Diabetes | SFEBES2021

Central adiposity and diabetes are causally associated with kidney stone disease

Lovegrove Catherine , Wiberg Akira , Littlejohns Thomas , Allen Naomi , Turney Benjamin , Mahajan Anubha , McCarthy Mark , Thakker Rajesh , Furniss Dominic , Howles Sarah

Introduction: The pathogenesis of kidney stone disease (KSD) is poorly understood and has been linked to features of metabolic syndrome (MetS). Using conventional and genetic epidemiological analyses we studied associations of MetS phenotypes with risk of KSD.Methods: Multivariate Cox-proportional hazard models were used to assess association of BMI and waist-hip ratio (WHR) with KSD in 492,380 UK Biobank participants. Causal relationships between WHR, B...

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ea0086ec1.2 | Early Career Prize Lecture Clinical | SFEBES2022

Central adiposity raises serum calcium concentrations and increases risk of kidney stone disease

Lovegrove Catherine , Besevic Jelena , Wiberg Akira , Lacey Ben , Littlejohns Thomas , Allen Naomi , Goldsworthy Michelle , Kim Jihye , Hannan Fadil , Curhan Gary , Turney Ben , McCarthy Mark , Mahajan Anubja , Thakker Rajesh , Holmes Michael , Furniss Dominic , Howles Sarah

Background: Kidney stone disease (KSD) has been linked to obesity, metabolic syndrome and higher serum calcium concentration (SCa). The mechanisms underlying these associations are uncertain. Using conventional and genetic epidemiological techniques, we aimed to investigate the effects of adiposity on KSD.Methods: Observational associations between adiposity and incident KSD in 479, 405 people from the UK Biobank were assessed. Genome-wide association st...

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Endocrine Abstracts

Central adiposity and diabetes are causally associated with kidney stone disease

Central adiposity raises serum calcium concentrations and increases risk of kidney stone disease

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